5-甲氧基吲哚-3-乙醇合成路线 （共 19 条）
反应条件
1.1: t-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 1.2: 56 percent / pentane; tetrahydrofuran / 0.25 h / -78 °C 2.1: 84 percent / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 p. 267 - 275
反应条件
1: triethylamine / 1 h / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 - 65 °C View Scheme
参考文献
WO2012/110986 A1, ;
WO 2012/110986 A1
参考文献
Heterocycles, , vol. 60, # 5 p. 1095 - 1110
反应条件
1: aq.-ethanolic KOH 2: ethanolic HCl 3: ethanol; sodium / 150 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 11, p. 221,222
反应条件
1: iodine; 1H-imidazole; triphenylphosphine 2: sodium azide / N,N-dimethyl-formamide 3: 10 Pd/C; hydrogen / methanol / 760.05 Torr View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4568 - 4571
反应条件
1: With tetrabutylammomium bromide; potassium hydroxide in dichloromethane; water T=-20°C; 5 h; 2: With bromine; triphenylphosphine in dichloromethane T=20°C; 6 h;
参考文献
Jafarpour, Farnaz; Hazrati, Hamideh
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 363 - 367
反应条件
1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 2.2: 18 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2012/110986 A1, 2012 ;
WO 2012/110986 A1
反应条件
1: iodine; 1H-imidazole; triphenylphosphine 2: sodium azide / N,N-dimethyl-formamide 3: 10 Pd/C; hydrogen / methanol / 760.05 Torr 4: triethylamine View Scheme
参考文献
Gore, Sangram; Baskaran, Sundarababu; Koenig, Burkhard
Organic Letters, 2012 , vol. 14, # 17 p. 4568 - 4571
反应条件
diethyl ether; phosphorus tribromide Erwaermen des Reaktionsprodukts in Methanol mit wss. Dimethylamin;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 11, p. 221,222
