2-氨基-4,7-二羟基-6-甲基蝶啶合成路线 （共 12 条）
反应条件
NaOD; sodium nitrite
参考文献
Landor; Rydon
Journal of the Chemical Society, 1955 , p. 1113,1115
反应条件
hydrogenchloride
28 h; Heating;
参考文献
Neilsen; Broadbent; Hennen
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1621 - 1628
反应条件
sodium hydroxide
28 h; Heating;
参考文献
Neilsen; Broadbent; Hennen
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1621 - 1628
反应条件
acetic acid
Erhitzen des Reaktionsprodukts mit wss.HCl;
参考文献
Matsuura et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 4446,4447
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Elion et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 78,79
反应条件
ethanol
Erhitzen des Reaktionsprodukts mit wss.H2SO4;
参考文献
Elion et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 78,79
反应条件
1: 1.) CH3ONa / 1.) methanol; 2.) reflux, 20 h.
2: 82 percent / 2percent aq. NaOH / 0.08 h / Heating
3: 96 percent / 10percent hydrochloric acid / 28 h / Heating
View Scheme
参考文献
Neilsen; Broadbent; Hennen
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1621 - 1628
反应条件
sodium hydroxide
0.75 h; Heating; Yield given;
参考文献
Neilsen; Broadbent; Hennen
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1621 - 1628
反应条件
1: 1.)C2H5ONa / 1.) ethanol, reflux, 3.5 h; 2.) reflux, 146 h.
2: 10percent aq. NaOH / 0.75 h / Heating
View Scheme
参考文献
Neilsen; Broadbent; Hennen
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1621 - 1628
反应条件
2: ozone / anschliessend Erwaermen mit wss. H2O2 in wss. HCl
View Scheme
参考文献
Karrer; Feigl
Helvetica Chimica Acta, 1951 , vol. 34, p. 2155,2156
参考文献
Pfleiderer
Chemische Berichte, 1957 , vol. 90, p. 2631,2633,2635
