5-(5-硝基-2-呋喃基)-1,3,4-噻二唑-2-基胺合成路线 (共 8 条)
反应条件
1: NaNO2, HCl / Cu 2: thiourea / ethanol / 78 °C View Scheme
参考文献
Foroumadi; Daneshtalab; Mahmoudian; Falahati; Nateghian; Shahsavarani; Shafiee
Pharmacy and Pharmacology Communications, 1998 , vol. 4, # 2 p. 95 - 98
反应条件
1: NaNO2; aq. HCl; Cu 2: thiourea / ethanol / Heating View Scheme
参考文献
Foroumadi, Alireza; Kargar, Zahra; Sakhteman, Amirhossein; Sharifzadeh, Zahra; Feyzmohammadi, Robabeh; Kazemi, Mahnoush; Shafiee, Abbas
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1164 - 1167
反应条件
NH4Fe(SO4)*12H2O in water
Cyclization; oxidation; 48 h; Heating;
参考文献
Foroumadi, Alireza; Daneshtalab, Mohsen; Shafiee, Abbas
Arzneimittel-Forschung/Drug Research, 1999 , vol. 49, # 12 p. 1035 - 1038
反应条件
iron(III) chloride in water
4 h; Heating;
参考文献
Chauviere, Gerard; Bouteille, Bernard; Enanga, Bertin; De Albuquerque, Cristina; Croft, Simon L.; Dumas, Michel; Perie, Jacques
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 427 - 440
反应条件
1: 90 percent / dimethylsulfoxide / 15 h / 20 °C
2: 65 percent / FeCl3*6H2O / H2O / 4 h / Heating
View Scheme
参考文献
Chauviere, Gerard; Bouteille, Bernard; Enanga, Bertin; De Albuquerque, Cristina; Croft, Simon L.; Dumas, Michel; Perie, Jacques
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 427 - 440
反应条件
1: HCl / ethanol / 1 h / Heating
2: aq. NH4Fe(SO4)2 / 16 h / Heating
View Scheme
参考文献
Foroumadi, Alireza; Pournourmohammadi, Shirin; Soltani, Fatemeh; Asgharian-Rezaee, Mitra; Dabiri, Shahriar; Kharazmi, Arsalan; Shafiee, Abbas
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 8 p. 1983 - 1985
参考文献
Sherman,W.R.
Journal of Organic Chemistry, 1961 , vol. 26, p. 88 - 95
反应条件
1: in ethanol
Reflux;
2: With ammonium iron(III) sulfate dodecahydrate in water
Reflux;
参考文献
Tahghighi, Azar; Marznaki, Farzane Rezazade; Kobarfard, Farzad; Dastmalchi, Siavoush; Mojarrad, Javid Shahbazi; Razmi, Sepideh; Ardestani, Sussan Kabudanian; Emami, Saeed; Shafiee, Abbas; Foroumadi, Alireza
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2602 - 2608