1H-苯并[d]咪唑-5,6-二胺合成路线 （共 4 条）
反应条件
1: 5,6-diaminobenzimidazole With sodium nitrite in sulfuric acid T=5°C; 0.5 h; 2: β-naphthol With sodium acetate in sodium hydroxide pH=5 - 6;
参考文献
Dincer, Sebla
Heterocyclic Communications, 2004 , vol. 10, # 2-3 p. 193 - 196
反应条件
1: With tin in hydrogenchloride
2: in ammonium hydroxide
参考文献
Dincer, Sebla
Heterocyclic Communications, 2004 , vol. 10, # 2-3 p. 193 - 196
反应条件
1.1: nitric acid; acetic acid / 0.5 h / 70 °C
1.2: Cooling with ice
2.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C
View Scheme
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: EP2532665 A1, 2012 ;
反应条件
1: sulfuric acid; nitric acid
2: 10 palladium on activated charcoal; hydrazine
View Scheme
参考文献
Shi, Shuo; Zhao, Juan; Gao, Xing; Lv, Chunyan; Yang, Li; Hao, Jian; Huang, Hailiang; Yao, Junliang; Sun, Wenliang; Yao, Tianming; Ji, Liangnian
Dalton Transactions, 2012 , vol. 41, # 19 p. 5789 - 5793
