2-甲氧基吡啶-3-甲醛合成路线 （共 13 条）
反应条件
1: 3-Bromo-2-methoxypyridine With n-butyllithium; isopropylmagnesium chloride in tetrahydrofuran; hexane T=-2 - 0°C; 0.75 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere;
参考文献
Struk, Lukasz; Sosnicki, Jacek G.
Synthesis, 2012 , vol. 44, # 5 p. 735 - 746
反应条件
4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide; N,N,N',N,-tetramethylethylenediamine 1.) hexane, THF, from -40 deg C to 0 deg C, 2.) hexane, THF, -40 deg C, 0.75 h; Yield given. Multistep reaction;
参考文献
Trecourt, F.; Mallet, M.; Marsais, F.; Queguiner, G.
Journal of Organic Chemistry, 1988 , vol. 53, # 7 p. 1367 - 1371
反应条件
2-Bromo-1,3,5-trimethyl-benzene; tert.-butyl lithium 1) THF, a) -78 deg C, b) 0 deg C, 1 h, c) room temperature, 1 h, 2) -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 55, # 1 p. 69 - 73
反应条件
4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide; methyllithium 1.) Et2O, THF, 0 deg C, 3 h, 2.) Et2O, THF, -40 deg C, 0.75 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 7 p. 1367 - 1371
反应条件
n-butyllithium; iodobenzene; diisopropylamine 1.) THF, 0 deg C, 3 h, 2.) -40 deg C, 30 min.; Yield given. Multistep reaction;
参考文献
Journal of Organometallic Chemistry, , vol. 406, # 1+2 p. 49 - 56
反应条件
4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide; methyllithium 1.) Et2O, THF, 0 deg C, 3 h, 2.) -70 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 7 p. 1367 - 1371
反应条件
1: 1) butyllithium, di-isopropylamide / 1) THF, hexane, 0 deg C, 1 h 2) THF, -70 deg C, 3 h 2: 1) MeOH, reflux, 5 h 2) hydrolysis View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 9 p. 2409 - 2415
反应条件
1) MeOH, reflux, 5 h 2) hydrolysis; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 9 p. 2409 - 2415
反应条件
4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide; methyllithium 1.) Et2O, THF, 0 deg C, 3 h, 2.) Et2O, THF, -70 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Trecourt, F.; Mallet, M.; Marsais, F.; Queguiner, G.
Journal of Organic Chemistry, 1988 , vol. 53, # 7 p. 1367 - 1371
反应条件
trimethylsilyl iodide in chloroform T=60°C; 1 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/135323 A1, 2006 ;
Location in patent: Page/Page column 60 ;
WO 2006/135323 A1
