6-噁双环[3.1.0]-3-己烯合成路线 （共 22 条）
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Chemical Communications, , # 18 p. 1968 - 1970
反应条件
tetrakis(triphenylphosphine) palladium(0) in dichloromethane T=0 - 5°C; 4 h;
参考文献
Gerdil, Raymond; Liu, Huiyou; Bernardinelli, Gerald
Helvetica Chimica Acta, 1999 , vol. 82, # 3 p. 418 - 434
反应条件
disodium hydrogenphosphate; sodium dihydrogenphosphate in water 0.166667 h; Ambient temperaturepH 7.7;
参考文献
Journal of the American Chemical Society, , vol. 104, # 6 p. 1658 - 1665
反应条件
1.1: 33 g / tetrakis(triphenylphosphine)palladium / tetrahydrofuran; dimethylsulfoxide / 3 h / Heating 2.1: pyridine; DMAP / CH2Cl2 / 20 h / 20 °C 3.1: Pseudomonas cepacia lipase; aq. NaOH; phosphate buffer / acetone / 18 h / pH 7 3.2: N-methylmorpholine N-oxide; OsO4 / acetone 4.1: p-toluenesulfonic acid / acetone / 15 h 5.1: NH3 / methanol / 6 h View Scheme
参考文献
Yin, Xueqiang; Schneller, Stewart W
Nucleosides, nucleotides and nucleic acids, 2004 , vol. 23, # 1-2 p. 67 - 76
反应条件
1: 24 percent / (Ph3P)4Pd / dimethylsulfoxide; tetrahydrofuran / a) 0 deg C to r.t., 2 h, b) overnight 2: H2 View Scheme
参考文献
Coe, Diane M.; Orr, David C.; Roberts, Stanley M.; Storer, Richard
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3378 - 3379
反应条件
1: (Ph3P)4Pd / tetrahydrofuran / 12 h
2: 38 percent / hexane / 24 h / 40 - 45 °C / Pseudomonas cepacia lipase (PS-30 Lipase)
3: aq. OsO4, N-methylmorpholine-N-oxide / tetrahydrofuran; acetone / 24 h
4: TsOH / acetone / 18 h
5: 100 percent / methanol. KOH / 0.5 h / Ambient temperature
6: pyridinium chlorochromate, pyridine, molecular sieves / CH2Cl2
View Scheme
参考文献
Biadatti, Thibaud; Esker, John L.; Johnson, Carl R.
Tetrahedron Asymmetry, 1996 , vol. 7, # 8 p. 2313 - 2320
反应条件
1: 95 percent / <Pd(PPh3)4> / CH2Cl2 / 4 h / 0 - 5 °C
2: 68 percent / NaHCO3, EDTANa2, CF3CO3H / CH2Cl2 / 0 deg C, 15 min, then room temp., 20 h
View Scheme
参考文献
Gerdil, Raymond; Liu, Huiyou; Bernardinelli, Gerald
Helvetica Chimica Acta, 1999 , vol. 82, # 3 p. 418 - 434
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Kirmse, Wolfgang; Loosen Karin
Chemische Berichte, 1981 , vol. 114, # 1 p. 400 - 404
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Kirmse, Wolfgang; Loosen Karin
Chemische Berichte, 1981 , vol. 114, # 1 p. 400 - 404
反应条件
(2-Th)Cu(Bu)(CN)Li2
1.) THF, room temperature, 1 h, 2.) -78 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tucci, Fabio C.; Chieffi, Andre; Comasseto, Joao V.; Marino, Joseph P.
Journal of Organic Chemistry, 1996 , vol. 61, # 15 p. 4975 - 4989
