5,6-二氟二氢吲哚-2-酮合成路线 （共 4 条）
反应条件
titanium tetrachloride; zinc in tetrahydrofuran T=20°C; 0.0833333 h; Inert atmosphere;
参考文献
Lin, Wei; Hu, Ming-Hua; Feng, Xian; Fu, Lei; Cao, Cheng-Pao; Huang, Zhi-Bin; Shi, Da-Qing
Tetrahedron Letters, 2014 , vol. 55, # 14 p. 2238 - 2242
反应条件
aluminium trichloride T=200 - 210°C; 4.5 h;
参考文献
Cervena; Metysova; Protiva
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 330 - 332
反应条件
1: 69 percent / pyridine / benzene / Ambient temperature 2: 57 percent / aluminium chloride / 4.5 h / 200 - 210 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 330 - 332
反应条件
1: With borane-THF in tetrahydrofuran T=70°C; 2 h; Inert atmosphere; 2: With hydrogenchloride; methanol; water in tetrahydrofuran 1 h; Reflux; 3: With sodium hydroxide in water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/195954 A1, 2011 ;
Location in patent: Page/Page column 104 ;
