3-羟基-4-硝基苯甲酸甲酯合成路线 (共 19 条)
反应条件
sulfuric acid T=65°C; 17 h;
参考文献
Yap, Jeremy L.; Cao, Xiaobo; Vanommeslaeghe, Kenno; Jung, Kwan-Young; Peddaboina, Chander; Wilder, Paul T.; Nan, Anjan; MacKerell, Alexander D.; Smythe, W. Roy; Fletcher, Steven
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 15 p. 2928 - 2933
参考文献
Yoshitomi Pharmaceuticals Industries, Ltd.
Patent: US6080738 A1, 2000 ;
US 6080738 A
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in methanol T=20°C; 6 h;
参考文献
Vutukuri, Dharma Rao; Bharathi, Pandi; Yu, Zhouying; Rajasekaran, Karthik; Tran, My-Huyen; Thayumanavan
Journal of Organic Chemistry, 2003 , vol. 68, # 3 p. 1146 - 1149
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere 2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 12 h / 20 °C 2.2: Acidic conditions View Scheme
参考文献
Azzarito, Valeria; Prabhakaran, Panchami; Bartlett, Alice I.; Murphy, Natasha S.; Hardie, Michaele J.; Kilner, Colin A.; Edwards, Thomas A.; Warriner, Stuart L.; Wilson, Andrew J.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6469 - 6472
反应条件
hydrogen; palladium on activated charcoal in ethanol 6 h;
参考文献
Samih, Fouzia; Prudhomme, Michelle; Dauphin, Gerard; Jeminet, Georges
Tetrahedron, 1990 , vol. 46, # 15 p. 5177 - 5186
参考文献
Heterocycles, , vol. 64, p. 193 - 198
反应条件
sodium tetrahydroborate; aluminium trichloride in diethylene glycol dimethyl ether 0.5 h; Heating; Yield given;
参考文献
Selivanov; Kulikov; Ginak
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 3 p. 394 - 400
反应条件
1: palladium on carbon; hydrogen / ethanol 2: ethanol 3: methanol; sodium hydroxide View Scheme
参考文献
Perrey, David A.; Gilmour, Brian P.; Runyon, Scott P.; Thomas, Brian F.; Zhang, Yanan
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2980 - 2985
反应条件
1: 99 percent / potassium carbonate / acetone / 4 h / Heating 2: hydrogen / Pd/C / methanol; tetrahydrofuran / 2327.17 Torr 3: 1.8 g / acetic acid / methanol; tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Ramesh, Chintakunta; Raju, B. Rama; Kavala, Veerababurao; Kuo, Chun-Wei; Yao, Ching-Fa
Tetrahedron, 2011 , vol. 67, # 6 p. 1187 - 1192