乙基3-(6-甲基-3-吡啶基)丙酸酯合成路线 （共 13 条）
反应条件
H2; perchloric acid; palladium in acetic acid
参考文献
Lonza Ltd.
Patent: US4687856 A1, 1987 ;
反应条件
hydrogen; palladium in water; acetic acid
参考文献
Lonza Ltd.
Patent: US4687856 A1, 1987 ;
反应条件
malonic acid; piperidine in pyridine
参考文献
Smith Kline and French Laboratories Limited
Patent: US4305945 A1, 1981 ;
US 4305945 A
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=45°C;
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: pyridine, piperidine
2: conc. H2SO4
3: H2 / 5percent Pd/C / ethanol / 45 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: conc. H2SO4
2: H2 / 5percent Pd/C / ethanol / 45 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
参考文献
Smith Kline and French Laboratories Limited
Patent: US4154834 A1, 1979 ;
US 4154834 A
反应条件
1: sodium wire / diethyl ether / 18 h / Ambient temperature
2: ethanol / 7 h / Heating
3: 59 percent / NaOH / H2O; ethanol / 60 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
sodium hydride in ethylene glycol dimethyl ether
20 h; Ambient temperature; Yield given;
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
in ethylene glycol dimethyl ether
参考文献
Smith Kline and French Laboratories Limited
Patent: US4305945 A1, 1981 ;
US 4305945 A
