乙基3-(6-甲基-3-吡啶基)丙酸酯合成路线 （共 13 条）
反应条件
in ethylene glycol dimethyl ether
参考文献
Smith Kline and French Laboratories Limited
Patent: US4305945 A1, 1981 ;
US 4305945 A
反应条件
1: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
2: sodium methoxide / methanol / 18 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
2: sodium methoxide / methanol / 18 h / Heating
3: 67 percent / 2.) ethanolic hydrogen chloride / ethanol / 24 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
