1-BOC-哌啶-3-羧酸合成路线 （共 37 条）
反应条件
1: 95 percent / 1-ethyl-3-(dimethylaminopropyl)carbodiimide*HCl; 1-hydroxybenzotriazole / CH2Cl2 / 20 °C 2: HCl / dioxane View Scheme
参考文献
Zhang, Li; Qiu, Beiying; Xiong, Bing; Li, Xin; Li, Jingya; Wang, Xin; Li, Jia; Shen, Jingkang
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2118 - 2122
反应条件
1: di-tert-butyl dicarbonate; NH4HCO3; pyridine / dioxane / 20 h / 20 °C 2: Et3N; trifluoroacetic anhydride / CH2Cl2 / 3.5 h / 20 °C View Scheme
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
反应条件
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 3 h / 85 °C 2: hydrogenchloride; water / 0 - 20 °C View Scheme
参考文献
Nencini, Arianna; Castaldo, Cristiana; Comery, Thomas A.; Dunlop, John; Genesio, Eva; Ghiron, Chiara; Haydar, Simon; Maccari, Laura; Micco, Iolanda; Turlizzi, Elisa; Zanaletti, Riccardo; Zhang, Jean
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 401 - 418
反应条件
1: H2SO4 2: 30 percent TFA / CH2Cl2 View Scheme
参考文献
Baek, Bong-Hyeon; Lee, Myung-Ryul; Kim, Kwang-Yon; Cho, Ung-In; Boo, Doo Wan; Shin, Injae
Tetrahedron Letters, 2003 , vol. 44, # 17 p. 3447 - 3450
反应条件
1: With chloroformic acid ethyl ester; triethylamine in chloroform T=0°C; 0.166667 h; 2: With ammonia in chloroform T=20°C; 4 h;
参考文献
ADDEX PHARMACEUTICALS SA
Patent: WO2006/123257 A2, 2006 ;
Location in patent: Page/Page column 34 ;
WO 2006/123257 A2
反应条件
diphenyl phosphoryl azide; triethylamine in toluene Curtius rearrangement; Reflux;
参考文献
Ma, Bin; Lee, Wen-Cherng
Tetrahedron Letters, 2010 , vol. 51, # 2 p. 385 - 386
反应条件
hydrogenchloride; triethylamine; benzyl alcohol in hexane; toluene
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
反应条件
1: With ruthenium(IV) oxide monohydrate; sodium perchlorate in water; ethyl acetate 3 h; 2: With hydrogenchloride in 1,4-dioxane 2 h;
参考文献
MERCK SHARP and DOHME CORP.; DING, Fa-Xing; JIANG, Jinlong; SHEN, Dong-Ming; SHI, Zhi-Cai; SHU, Min; YANG, Cangming
Patent: WO2011/146354 A1, 2011 ;
Location in patent: Page/Page column 65 ;
反应条件
1: triethylamine; HATU / dichloromethane 2: diethyl ether; tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
WO2012/58127 A2, ;
WO 2012/058127 A2
反应条件
T=120°C; neat (no solvent);
参考文献
Lavrador-Erb, Karine; Ravula, Satheesh Babu; Yu, Jinghua; Zamani-Kord, Said; Moree, Wilna J.; Petroski, Robert E.; Wen, Jianyun; Malany, Siobhan; Hoare, Samuel R.J.; Madan, Ajay; Crowe, Paul D.; Beaton, Graham
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2916 - 2919
