1-BOC-哌啶-3-羧酸合成路线 （共 37 条）
反应条件
hydrogenchloride in 1,4-dioxane; water
参考文献
Hinks; Jeremy David; Takle; Andrew Kenneth; Hunt; Eric
Patent: US6020368 A1, 2000 ;
反应条件
sodium hydroxide in tetrahydrofuran
48 h; Ambient temperature;
参考文献
Villalgordo, Jose M.; Heimgartner, Heinz
Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
University of Pittsburgh
Patent: US6310095 B1, 2001 ;
反应条件
triethylamine in acetonitrile
24 h;
参考文献
PIRAMED LIMITED
Patent: WO2006/46031 A1, 2006 ;
Location in patent: Page/Page column 81 ;
WO 2006/046031 A1
反应条件
triethylamine in 1,4-dioxane; water
T=20°C;
参考文献
Catalano, Alessia; Carocci, Alessia; Corbo, Filomena; Franchini, Carlo; Muraglia, Marilena; Scilimati, Antonio; De Bellis, Michela; De Luca, Annamaria; Camerino, Diana Conte; Sinicropi, Maria Stefania; Tortorella, Vincenzo
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 11 p. 2535 - 2540
反应条件
sodium hydroxide; dimethyl sulfoxide in 1,4-dioxane; hexane; dichloromethane; ethyl acetate
参考文献
Bayer Aktiengesellschaft
Patent: US6562811 B1, 2003 ;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US5707994 A1, 1998 ;
反应条件
1: 93 percent / Huenig base / CH2Cl2 / 0 deg C to RT
2: 100 percent / 4 N NaOH / tetrahydrofuran / 48 h / Ambient temperature
View Scheme
参考文献
Villalgordo, Jose M.; Heimgartner, Heinz
Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222
反应条件
1: 93 percent / Huenig base / CH2Cl2 / 0 deg C to RT
2: 100 percent / 4 N NaOH / tetrahydrofuran / 48 h / Ambient temperature
View Scheme
参考文献
Villalgordo, Jose M.; Heimgartner, Heinz
Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222
反应条件
1.1: hexane; diethyl ether; methanol / 4 h / 20 °C
2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere
2.2: 5 h / -78 °C
3.1: ozone; oxygen / dichloromethane; methanol / 2.17 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 °C / Cooling with ice-water bath
3.3: 20 °C / Cooling
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John
Patent: WO2011/141728 A1, 2011 ;
WO 2011/141728 A1
