7-乙氧基-4H-苯并[1,4]噻嗪-3-酮合成路线 （共 7 条）
反应条件
sulfuric acid in ethanol
electrolysis;
参考文献
Sicker, Dieter; Hartenstein, Holger; Hazard, Roland; Tallec, Andre
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 809 - 812
反应条件
1: BPSS2111-2113:A With potassium carbonate in ethanol
0.5 h; Reflux;
2: ethyl bromide in ethanol
Reflux;
参考文献
Zhang, Li-Qiu; Guan, Li-Ping; Wei, Cheng-Xi; Deng, Xian-Qing; Quan, Zhe-Shan
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 3 p. 326 - 331
反应条件
1.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C
2.1: potassium carbonate / acetonitrile / 0.5 h / |Reflux
2.2: |Reflux
View Scheme
参考文献
Cao, Xu; Wang, Shi-Ben; Deng, Xian-Qing; Liu, Da-Chuan; Quan, Zhe-Shan
Medicinal Chemistry Research, 2014 , vol. 23, # 4 p. 1829 - 1838
反应条件
1.1: sodium hydrogencarbonate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 2.67 h / 0 °C / |Reflux
2.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C
3.1: potassium carbonate / acetonitrile / 0.5 h / |Reflux
3.2: |Reflux
View Scheme
参考文献
Cao, Xu; Wang, Shi-Ben; Deng, Xian-Qing; Liu, Da-Chuan; Quan, Zhe-Shan
Medicinal Chemistry Research, 2014 , vol. 23, # 4 p. 1829 - 1838
反应条件
1.1: potassium hydroxide / water / 20 h / |Reflux
2.1: sodium hydrogencarbonate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 2.67 h / 0 °C / |Reflux
3.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C
4.1: potassium carbonate / acetonitrile / 0.5 h / |Reflux
4.2: |Reflux
View Scheme
参考文献
Cao, Xu; Wang, Shi-Ben; Deng, Xian-Qing; Liu, Da-Chuan; Quan, Zhe-Shan
Medicinal Chemistry Research, 2014 , vol. 23, # 4 p. 1829 - 1838
参考文献
Sicker, Dieter; Hartenstein, Holger; Hazard, Roland; Tallec, Andre
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 809 - 812
参考文献
Cassella and Co.
Patent: DE371258 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 924
