potassium hydroxide; water

hydrogenchloride; water 3 h; Reflux;

potassium phosphate in water; N,N-dimethyl-formamide

1: sodium borohydride / methanol / 1.5 h / 0 °C 2: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C 3: diethyl ether; xylene / 48 h / 100 °C 4: 69.3 percent / butylene oxide / 12 h / 65 °C 5: 86 percent / potassium hydroxide / H2O; ethanol / 3 h / 50 °C View Scheme

1: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C 2: diethyl ether; xylene / 48 h / 100 °C 3: 69.3 percent / butylene oxide / 12 h / 65 °C 4: 86 percent / potassium hydroxide / H2O; ethanol / 3 h / 50 °C View Scheme

1: n-BuLi / diethyl ether 2: aq. LiOH View Scheme

1: diethyl ether; xylene / 48 h / 100 °C 2: 69.3 percent / butylene oxide / 12 h / 65 °C 3: 86 percent / potassium hydroxide / H2O; ethanol / 3 h / 50 °C View Scheme

2: aq. KOH / ethanol View Scheme

2: aq. KOH / ethanol View Scheme

1.1: n-butyllithium / tetrahydrofuran / -78 °C 1.2: 20 °C 2.1: tetrahydrofuran; hexane / 0.17 h / 0 - 20 °C / |Inert atmosphere 2.2: 2 h / |Reflux; |Inert atmosphere 3.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 4.1: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 5.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 6.1: water; hydrogenchloride / 3 h / |Reflux View Scheme