2-[4-(4,5-二氢-1H-咪唑-2-基)-苯基]-乙胺合成路线 （共 8 条）
反应条件
hydrazine in ethanol
T=20°C; 2 h;
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2007/72092 A2, 2007 ;
Location in patent: Page/Page column 21 ;
WO 2007/072092 A2
反应条件
1: 4-(2-azidoethyl)benzonitrile With hydrogenchloride in ethyl acetate
T=0 - 20°C;
2: ethylenediamine in ethanol
参考文献
Su, Dai-Shi; Bock, Mark G.
Patent: US2005/20591 A1, 2005 ;
Location in patent: Page/Page column 13 ;
US 20050020591 A1
反应条件
trifluoroacetic acid in dichloromethane
T=0 - 20°C; 2 h;
参考文献
GRUeNENTHAL GMBH; MERLA, Beatrix; OBERBOeRSCH, Stefan; REICH, Melanie; SCHUNK, Stefan; JOSTOCK, Ruth; HEES, Sabine; ENGELS, Michael; GERMANN, Tieno; BIJSTERVELD, Edward
Patent: WO2010/99938 A1, 2010 ;
Location in patent: Page/Page column 118-119 ;
反应条件
1: [(4-cyanophenyl)methyl]methanamine With hydrogenchloride in ethyl acetate
T=0 - 20°C;
2: ethylenediamine in ethanol
参考文献
MERCK and CO., INC.
Patent: WO2004/54584 A1, 2004 ;
Location in patent: Page/Page column 23-24 ;
WO 2004/054584 A1
参考文献
MERCK and CO., INC.
Patent: WO2004/83173 A2, 2004 ;
Location in patent: Page 29 ;
WO 2004/083173 A2
反应条件
1: hydrogenchloride
3: hydrazine hydrate / ethanol
View Scheme
参考文献
Eles, Janos; Beke, Gyula; Vago, Istvan; Bozo, Eva; Huszar, Jozsef; Tarcsay, Akos; Kolok, Sandor; Schmidt, Eva; Vastag, Monika; Hornok, Katalin; Farkas, Sandor; Domany, Gyoergy; Keser, Gyoergy M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3095 - 3099
反应条件
2: hydrazine hydrate / ethanol
View Scheme
参考文献
Eles, Janos; Beke, Gyula; Vago, Istvan; Bozo, Eva; Huszar, Jozsef; Tarcsay, Akos; Kolok, Sandor; Schmidt, Eva; Vastag, Monika; Hornok, Katalin; Farkas, Sandor; Domany, Gyoergy; Keser, Gyoergy M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3095 - 3099
反应条件
1: triphenylphosphine; diethylazodicarboxylate / N,N-dimethyl-formamide / 20 °C
2: hydrogenchloride
4: hydrazine hydrate / ethanol
View Scheme
参考文献
Eles, Janos; Beke, Gyula; Vago, Istvan; Bozo, Eva; Huszar, Jozsef; Tarcsay, Akos; Kolok, Sandor; Schmidt, Eva; Vastag, Monika; Hornok, Katalin; Farkas, Sandor; Domany, Gyoergy; Keser, Gyoergy M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3095 - 3099
