N,N-双-(2-羟乙基)-对甲苯磺酰胺合成路线 （共 16 条）
反应条件
Yield given. Multistep reaction;
参考文献
Vries, Erik F. J. de; Steenwinkel, Pablo; Brussee, Johannes; Kruse, Chris G.; Gen, Arne van der
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4315 - 4325
反应条件
1: 84 percent / thionyl chloride / 1 h / 110 °C
2: 80 percent / NaNH2 / toluene / 1 h / Heating
3: 93 percent / water, H2SO4 / 3 h / Heating
View Scheme
参考文献
Al-Rashood; Madani; Ginawi; Ashraf; El-Obeid
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 11 p. 1242 - 1245
反应条件
1: Py
2: KF / bis-(2-hydroxy-ethyl) ether / 130 - 140 °C
View Scheme
参考文献
Pettit,G.R.; Smith,R.L.
Canadian Journal of Chemistry, 1964 , vol. 42, p. 572 - 578
反应条件
sodium hydride
1.) THF, mineral oil, reflux, 2 h, 2.) THF, reflux, 48 h; Yield given. Multistep reaction;
参考文献
Vries, Erik F. J. de; Steenwinkel, Pablo; Brussee, Johannes; Kruse, Chris G.; Gen, Arne van der
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4315 - 4325
反应条件
triethylamine in dichloromethane
T=-10°C; 0.25 h;
参考文献
Bartsch, Richard A.; Chapoteau, Eddy; Czech, Bronislaw P.; Krzykawski, Jan; Kumar, Anand; Robison, Thomas W.
Journal of Organic Chemistry, 1994 , vol. 59, # 3 p. 616 - 621
反应条件
triethylamine in dichloromethane
参考文献
U C B, S.A.
Patent: US5478941 A1, 1995 ;
