(2S)-N-苄氧羰基-2-吡咯烷甲醛合成路线 （共 7 条）
反应条件
1: 90.5 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h 2: 98 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr View Scheme
参考文献
Mazzini, Claudio; Sambri, Letitia; Regeling, Henk; Zwanenburg, Binne; Chittenden, Gordon J. F.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 22 p. 3351 - 3356
反应条件
ammonium hydroxide; iodine in tetrahydrofuran T=25°C;
参考文献
Shie, Jiun-Jie; Fang, Jim-Min
Journal of Organic Chemistry, 2007 , vol. 72, # 8 p. 3141 - 3144
反应条件
sodium chlorite; disodium hydrogenphosphate in various solvent(s) 1 h;
参考文献
Mazzini, Claudio; Sambri, Letitia; Regeling, Henk; Zwanenburg, Binne; Chittenden, Gordon J. F.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 22 p. 3351 - 3356
反应条件
sodium tetrahydroborate in methanol 0.5 h;
参考文献
Mazzini, Claudio; Sambri, Letitia; Regeling, Henk; Zwanenburg, Binne; Chittenden, Gordon J. F.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 22 p. 3351 - 3356
反应条件
1: Methyltriphenylphosphonium bromide With potassium hexamethylsilazane in tetrahydrofuran
T=20°C; 1 h;
2: (2S)-N-Cbz-pyrrolidine-2-carboxaldehyde in tetrahydrofuran
T=-78 - 20°C; Wittig reaction; 2.16667 h;
参考文献
Scapecchi, Serena; Matucci, Rosanna; Bellucci, Cristina; Buccioni, Michela; Dei, Silvia; Guandalini, Luca; Martelli, Cecilia; Manetti, Dina; Martini, Elisabetta; Marucci, Gabriella; Nesi, Marta; Romanelli, Maria Novella; Teodori, Elisabetta; Gualtieri, Fulvio
Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 1925 - 1931
反应条件
triphenylphosphine; RhCl(PPh3)3 in tetrahydrofuran; isopropyl alcohol
T=20°C;
参考文献
Ngashima, Hideo; Gondo, Mitsuru; Masuda, Satoshi; Kondo, Hideo; Yamaguchi, Yoshitaka; Matsubara, Kouki
Chemical Communications (Cambridge, United Kingdom), 2003 , # 3 p. 442 - 444
反应条件
1: ceric trichloride / methanol / room temp. for 0.5 h. then 50 gradC for 21 h.
2: H2 / Pd/C
3: 77 percent / diethyl phosphorocyanidate, triethylamine, molecular sieves 4A / tetrahydrofuran / 0 gradC for 1 h. then room temp. for 40 min.
5: 80 percent / H2 / palladium-carbon / ethanol
View Scheme
参考文献
Mori, Shigehiro; Aoyama, Toyohiko; Shioiri, Takayuki
Tetrahedron Letters, 1986 , vol. 27, # 50 p. 6111 - 6114
