(3B,5A)-雄甾-16-烯-3-醇合成路线 （共 14 条）
反应条件
Stage #1: <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '610130', constants.ctx, '0')">toluene-4-sulfonic acid hydrazide</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br />Bamford-Stevens Decomposition; 2 h; Reflux; <br />Stage #2: <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '3587162', constants.ctx, '0')">methyllithium</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=22°C; Bamford-Stevens Decomposition; 16.5 h; <br />
参考文献
Starkenmann, Christian; Mayenzet, Fabienne; Brauchli, Robert; Troccaz, Myriam Chemistry and Biodiversity, 2013 , vol. 10, # 12 p. 2197 - 2208
反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1: Aspergillus tamarii KITA (QM 1223) / N,N-dimethyl-formamide / 120 h / 30 °C / Microbiological reaction<br />2: hydrazine hydrate; triethylamine / ethanol / 3 h / Reflux<br />3: iodine; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere<br />4: sodium / ethanol<br /> <br />
参考文献
Hunter, A. Christy; Collins, Catherine; Dodd, Howard T.; Dedi, Cinzia; Koussoroplis, Salome-Juliette Journal of Steroid Biochemistry and Molecular Biology, 2010 , vol. 122, # 5 p. 352 - 358
反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1: 92 percent / pyridine / 24 h / 0 °C<br />2: 87 percent / toluene / 480 °C<br />3: 1.) lithium tris(1,2-dimethylpropyl)hydridoborate; 2.) water, ethanol / 1.) THF, r.t., 3 h; 2.) -55 deg C<br /> <br />
参考文献
Ohloff; Maurer; Winter; Giersch Helvetica Chimica Acta, 1983 , vol. 66, # 1 p. 192 - 217
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: 87 percent / pyridine / 48 h / 28 °C<br />2: 31 percent / NaNO<sub>2</sub> / dimethylsulfoxide / 29 h / 90 °C<br /> <br />
参考文献
Kasal, Alexander; Fuksova, Kveta; Pouzar, Vladimir Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 3 p. 600 - 611
