2 -甲基- 3 -硝基苯合成路线 （共 12 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; palladium diacetate; sodium carbonate; 1,2-bis-(diphenylphosphino)ethane; potassium iodide in N,N-dimethyl-formamide T=130°C; 22 h; Inert atmosphere;
参考文献
Zheng, Shuyan; Yu, Chunhui; Shen, Zhengwu
Organic Letters, 2012 , vol. 14, # 14 p. 3644 - 3647
反应条件
pyridine T=220°C; 3.5 h; Sealed tubeInert atmosphere;
参考文献
Jin, Cheng Hua; Krishnaiah, Maddeboina; Sreenu, Domalapally; Subrahmanyam, Vura B.; Rao, Kota S.; Lee, Hwa Jeong; Park, So-Jung; Park, Hyun-Ju; Lee, Kiho; Sheen, Yhun Yhong; Kim, Dae-Kee
Journal of Medicinal Chemistry, 2014 , vol. 57, # 10 p. 4213 - 4238
反应条件
zeolite Hβ; trifluoroacetyl nitrate; acetic anhydride T=-10°C; Nitration;
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 16 p. 2753 - 2758
反应条件
2.) CuCN Multistep reaction;
参考文献
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 53, # 2 p. 141 - 150
反应条件
1: Zn / H2O; ethanol 2: 2.) NaN3 View Scheme
参考文献
Dunkin; Shields
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1997 , vol. 53, # 2 p. 141 - 150
反应条件
1: aqueous sulfuric acid / 150 °C 2: thionyl chloride 3: benzene; pyridine 4: Raney nickel; ethanol / Hydrieren des Reaktionsprodukts an Raney-Nickel in Aethanol View Scheme
参考文献
Sorkin; Kraehenbuehl; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 65,74
反应条件
1: tin dichloride; concentrated hydrochloric acid; absolute alcohol 2: Diazotization View Scheme
参考文献
Noelting
Chemische Berichte, 1904 , vol. 37, p. 1021
反应条件
sulfuric acid T=150°C;
参考文献
Sorkin; Kraehenbuehl; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 65,74
反应条件
1: 4 h / 110 °C 2: TiCl3, 4M NH4OAc / acetone View Scheme
参考文献
Lloyd, David H.; Nichols, David E.
Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4561 - 4562
反应条件
1: aqueous sulfuric acid / 150 °C 2: thionyl chloride 3: benzene; pyridine 4: Raney nickel; ethanol / Hydrieren des Reaktionsprodukts an Raney-Nickel in Aethanol 5: copper (I)-copper (II)-sulfite; aqueous HCl; NaNO2 View Scheme
参考文献
Sorkin; Kraehenbuehl; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 65,74
