6,7-二甲氧基-2-甲苯磺酰-2,3-二氢异喹啉-4(1H)-酮合成路线 （共 4 条）
反应条件
AlCl3, aluminium chloride in dichloromethane
T=-78 - -10°C; 8 h;
参考文献
AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2007/103554 A1, 2007 ;
Location in patent: Page/Page column 60 ;
反应条件
iodine; triphenylphosphine in benzene
Ambient temperature;
参考文献
Ponzo, Viviana L.; Bianchi, Dario A.; Kaufman, Teodoro S.
Tetrahedron Letters, 1998 , vol. 39, # 21 p. 3409 - 3412
反应条件
1: OsO4, NMO / acetone; 2-methyl-propan-2-ol; H2O / Ambient temperature
2: trimethyl orthoformate, TsOH / CH2Cl2 / Ambient temperature
3: 75 percent / PPh3, I2 / benzene / Ambient temperature; var. substituted tetrahydroisoquinolines
View Scheme
参考文献
Ponzo, Viviana L.; Bianchi, Dario A.; Kaufman, Teodoro S.
Tetrahedron Letters, 1998 , vol. 39, # 21 p. 3409 - 3412
反应条件
ethanol; water; sodium hydrogencarbonate
Heating / reflux;
参考文献
AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2007/103554 A1, 2007 ;
Location in patent: Page/Page column 61 ;
