1-(2-氨乙基)吡咯烷合成路线 （共 28 条）
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine in DMF (N,N-dimethyl-formamide) T=20°C; 2 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/34272 A1, 2007 ;
Location in patent: Page/Page column 17-18 ;
WO 2007/034272 A1
反应条件
triethylamine in dichloromethane 3 h;
参考文献
TARGEGEN, INC.
Patent: WO2008/8234 A1, 2008 ;
Location in patent: Page/Page column 105 ;
反应条件
in 1,4-dioxane 1 h; Ambient temperature;
参考文献
Vega; Alonso; Diaz; Junquera
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 269 - 273
反应条件
in N,N-dimethyl-formamide T=80°C; Yield given;
参考文献
Farmaco, , vol. 45, # 1 p. 29 - 38
反应条件
1: 85 percent / dioxane / 1 h / Ambient temperature 2: 92 percent / sodium borohydride / methanol; CHCl3 / 0.75 h / Ambient temperature View Scheme
参考文献
Vega; Alonso; Diaz; Junquera
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 269 - 273
反应条件
in benzene T=50 - 55°C; 24 h;
参考文献
Ronsisvalle, Giuseppe; Pappalardo, Maria S.; Vittorio, Franco; Pasquinucci, Lorella; Caruso, Antonina; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 553 - 560
参考文献
Wermuth; Schlewer; Bourguignon; Maghioros; Bouchet; Moire; Kan; Worms; Biziere
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 528 - 537
反应条件
in tetrachloromethane
3 h; Ambient temperature; Yield given;
参考文献
Baggaley; English; Jennings; Morgan; Nunn; Tyrrell
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1661 - 1667
参考文献
van Alphen
Recueil des Travaux Chimiques des Pays-Bas, 1939 , vol. 58, p. 1105,1106
反应条件
2: ethanol; sodium
View Scheme
参考文献
van Alphen
Recueil des Travaux Chimiques des Pays-Bas, 1939 , vol. 58, p. 1105,1106
