1: sodium ethylate 2: zinc; alcohol View Scheme

methanol; potassium carbonate

potassium hydroxide

暂无反应条件数据

1: 96 percent / (PhMe2Si)2CuLi*LiCN / tetrahydrofuran / 0.5 h / 0 °C 3: ICl / CH2Cl2 / 2 h / Heating 4: 98 percent / Et3N / CHCl3 / 3 h / 0 deg C -> RT 5: (n-Bu)3SnH, AIBN / benzene / 12 h / Heating 6: 65 percent / KOH, DMSO / 16 h / 60 °C 7: 75 percent / KHCO3, 70percent aq. H2O2 / tetrahydrofuran; methanol / Heating 8: 88 percent / pyridine, DMAP / CH2Cl2 / 72 h / 0 °C 9: 90 percent / pyridine 10: 1. (n-Bu)3SnH, AIBN 2. PPTS, EtOH / 1. toluene, 8h, reflux 2. THF, 60 deg C View Scheme

1: 4-methyl-pent-1-yne With n-butyllithium in tetrahydrofuran; hexanes T=-78 - 20°C; 2: 1-iodo-propane in tetrahydrofuran; hexanes T=20°C; 72 h;

(TPP)Zr(O2tBu)2 in benzene T=0°C; 72 h; Yield given. Yields of byproduct given;

1: 100 percent / MnO2 / CH2Cl2 / 2 h / 0 °C View Scheme

(TPP)Zr(O2tBu)2 in benzene T=0°C; 72 h; Yield given. Yields of byproduct given;

1: 4-methyl-pent-1-yne With ethylmagnesium bromide in tetrahydrofuran T=20°C; 1 h; Inert atmosphere; 2: oxirane in tetrahydrofuran T=20°C; 3: With ammonium chloride in tetrahydrofuran; water