1-甲基-3-（3-氧代环己烯-1-基）氮杂卓-2-酮合成路线 （共 11 条）
反应条件
1: 88 percent / bromine / CH2Cl2 / 1 h / 30 °C 2: 1.) butyl lithium, diisopropylamine / 1.) hexane/THF, reflux, 3 h, 2.) reflux, 3 h 3: 90 percent / lithium aluminium hydride / tetrahydrofuran / Heating View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
1: 88 percent / bromine / CH2Cl2 / 1 h / 30 °C 2: 1.) butyl lithium, diisopropylamine / 1.) hexane/THF, reflux, 3 h, 2.) reflux, 3 h View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
1: 88 percent / bromine / CH2Cl2 / 1 h / 30 °C 2: 90 percent / aq. sodium hydroxide / Ambient temperature 3: 1.) sodium amide / 1.) toluene, reflux, 2 h, 2.) THF, 2 h 4: 84 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating 5: 92 percent / 12 M hydrochloric acid / 48 h / Heating View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
hydrogenchloride; n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
参考文献
John Wyeth and Brother Limited
Patent: US4197241 A1, 1980 ;
反应条件
magnesium; diisopropylamine in tetrahydrofuran; dichloromethane; ethyl acetate
参考文献
John Wyeth and Brother Limited
Patent: US4197241 A1, 1980 ;
反应条件
1: 1.) sodamide / 1.) toluene, reflux, 30 min, 2.) toluene, reflux, 30 min
2: 1.) butyl lithium, diisopropylamine / 1.) hexane/THF, 0 to -10 deg C, 10 min, 2.) THF, amb. temp., 1.5 h
View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
n-butyllithium; diisopropylamine
1.) hexane/THF, 0 to -10 deg C, 10 min, 2.) THF, amb. temp., 1.5 h; Yield given. Multistep reaction;
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
1: 88 percent / bromine / CH2Cl2 / 1 h / 30 °C
2: 90 percent / aq. sodium hydroxide / Ambient temperature
3: 1.) sodium amide / 1.) toluene, reflux, 2 h, 2.) THF, 2 h
View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
1: 88 percent / bromine / CH2Cl2 / 1 h / 30 °C
2: 90 percent / aq. sodium hydroxide / Ambient temperature
3: 1.) sodium amide / 1.) toluene, reflux, 2 h, 2.) THF, 2 h
4: 84 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
1: 88 percent / bromine / CH2Cl2 / 1 h / 30 °C
2: 90 percent / aq. sodium hydroxide / Ambient temperature
View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
