5-(4-溴苯基)-3-甲基-1,2,4-噁二唑合成路线 （共 4 条）
反应条件
1: T=125°C; 2 h; 2: With sodium hydroxide; hydroxylamine hydrochloride; acetic acid in 1,4-dioxane; water T=20 - 90°C; 3.5 h; 3: With potassium carbonate in 1,4-dioxane; water
参考文献
WO2004/101546 A1, ;
Page 29-30 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; TEA in toluene T=95°C; P=760 Torr; 15 h;
参考文献
Young, Jonathan R.; DeVita, Robert J.
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 3931 - 3934
反应条件
sodium hydroxide; hydroxylamine hydrochloride; acetic acid
参考文献
Journal of Organic Chemistry, , vol. 44, # 23 p. 4160 - 4164
反应条件
1: T=125°C; 2 h; 2: With sodium hydroxide; hydroxylamine hydrochloride; acetic acid in 1,4-dioxane; water T=20 - 90°C; 3.5 h;
参考文献
WO2005/14571 A1, ;
Page/Page column 22 ;
WO 2005/014571 A1
