1: 2-iodo-4-methoxy-benzoic acid With tetrabutylammomium bromide; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=20°C; 0.166667 h; 2: allenyl tributylstannane in N,N-dimethyl-formamide T=80°C;

1: With pyridine in diethyl ether 2: With sodium hydroxide Heating; 3: With perchloric acid; acetic anhydride in ethyl acetate Further stages.;

potassium phosphate; copper(l) iodide in N,N-dimethyl-formamide T=120°C; 24 h; Inert atmosphere;

trifluorormethanesulfonic acid in toluene 0.05 h; Microwave irradiation; regioselective reaction;

1.1: sodium nitrite; hydrogenchloride / water / 0.5 h / 0 - 5 °C 1.2: 4 h / 5 - 20 °C 2.1: dihydrogen peroxide; sodium carbonate / acetone / 1 h / 5 - 20 °C 3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.25 h / 20 °C / |Inert atmosphere 4.1: trifluorormethanesulfonic acid / toluene / 0.05 h / |Microwave irradiation View Scheme

1: dihydrogen peroxide; sodium carbonate / acetone / 1 h / 5 - 20 °C 2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.25 h / 20 °C / |Inert atmosphere 3: trifluorormethanesulfonic acid / toluene / 0.05 h / |Microwave irradiation View Scheme

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.25 h / 20 °C / |Inert atmosphere 2: trifluorormethanesulfonic acid / toluene / 0.05 h / |Microwave irradiation View Scheme