1-[3,5-二-(1-甲基-1-氰基)乙基]苄基-1,2,4三氮唑,啊那曲唑合成路线 (共 7 条)
反应条件
1: With selenium(IV) oxide; ytterbium(III) triflate in 1,4-dioxane; water T=90°C; 18 h; 2: With sodium hydroxide in water 3: With hydrogenchloride in water pH=1;
参考文献
LABORATOIRE BIODIM; CHASSET, Sophie; CHEVREUIL, Francis; LEDOUSSAL, Benoit; LE STRAT, Frederic; BENAROUS, Richard
Patent: WO2012/140243 A1, 2012 ;
Location in patent: Page/Page column 61; 80 ;
反应条件
selenium(IV) oxide in 1,4-dioxane; water T=90°C; Cannizzaro Reaction; 24 h;
参考文献
Shen, Ming-Gui; Shang, Shi-Bin; Song, Zhan-Qian; Wang, Dan; Rao, Xiao-Ping; Gao, Hong; Liu, He
Journal of Chemical Research, 2013 , vol. 37, # 1 p. 51 - 52
反应条件
hydrogenchloride T=20 - 70°C; 42 h;
参考文献
DeSantis, Grace; Zhu, Zuolin; Greenberg, William A.; Wong, Kelvin; Chaplin, Jenny; Hanson, Sarah R.; Farwell, Bob; Nicholson, Lawrence W.; Rand, Cynthia L.; Weiner, David P.; Robertson, Dan E.; Burk, Mark J.
Journal of the American Chemical Society, 2002 , vol. 124, # 31 p. 9024 - 9025
反应条件
1: CH3COOH / methanol / 1 h / 0 °C 2: 70 percent / HCl / 42 h / 20 - 70 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 31 p. 9024 - 9025
反应条件
potassium hydroxide; lithium chloride in 1,4-dioxane T=10 - 15°C; Addition;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 900 - 910
参考文献
US6864240 B1, ;
US 6864240 B1
反应条件
oxygen; copper diacetate in dimethyl sulfoxide T=120°C; 10 h; Sealed tube;
参考文献
Feng, Qiang; Song, Qiuling
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1867 - 1871