(3-羟基-苯基)-氨基甲酸乙酯合成路线 （共 22 条）
反应条件
in ethyl acetate Heating;
参考文献
Maly, Dustin J.; Leonetti, Francesco; Backes, Bradley J.; Dauber, Deborah S.; Harris, Jennifer L.; Craik, Charles S.; Ellman, Jonathan A.
Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 910 - 915
反应条件
sodium ethanolate in ethanol; (methyl)isobutyl ketone; isobutyl methylketone
参考文献
Schering Aktiengesellschaft
Patent: US4164414 A1, 1979 ;
反应条件
1: sulfuric acid / 0 °C 2: sulfuric acid; acetic acid / Reflux View Scheme
参考文献
Sekine; Itakura; Namihisa; Takahashi; Nakayama; Kanaoka
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3286 - 3289
反应条件
1: 63 percent / 70percent H2SO4 / 8 h / 20 °C 2: NaOH; H2O / 16 h / Heating View Scheme
参考文献
Kanaoka; Kobayashi; Sato; Nakayama; Ueno; Muno; Sekine
Chemical and pharmaceutical bulletin, 1984 , vol. 32, # 10 p. 3926 - 3933
反应条件
1: 81 percent / 75percent H2SO4 / 4 h / Ambient temperature 2: 82 percent / conc H2SO4 / acetic acid / 3 h / Heating 3: 62 percent / Et3N / tetrahydrofuran; dimethylformamide / -5 deg C, 1 h, RT, 4 h 4: 68 percent / H2 / 10percent Pd-C / aq. acetic acid / 4 h View Scheme
参考文献
Sekine; Itakura; Namihisa; Takahashi; Nakayama; Kanaoka
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3286 - 3289
反应条件
1.1: sulfuric acid / ethanol / 20 °C 2.1: sulfuric acid; acetic acid / 4 h / Reflux 2.2: Cooling View Scheme
参考文献
Kathuria, Abha; Priya, Nivedita; Chand, Karam; Singh, Prabhjot; Gupta, Anjali; Jalal, Sarah; Gupta, Shilpi; Raj, Hanumantharao G.; Sharma, Sunil K.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 4 p. 1624 - 1638
反应条件
1: NaOH / H2O / 24 h / Ambient temperature 2: methanol / Heating View Scheme
参考文献
Kettmann; Csollei; Racanska; Svec
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 843 - 851
反应条件
1: NaOH / H2O / 24 h / Ambient temperature 2: methanol / Heating View Scheme
参考文献
Kettmann; Csollei; Racanska; Svec
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 843 - 851
反应条件
1: 2.) 75percent aq. H2SO4 / 2.) 25 deg C 2: 1.) KOH, 2.) H2SO4, AcOH / 1.) MeOH, reflux, 2.) reflux View Scheme
参考文献
Feng, Yangbo; Burgess, Kevin; Pledger, David; Cairns, Nick; Linthicum, D. Scott
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 881 - 884
参考文献
Kemisk Vaerk Koge A/S
Patent: US4748265 A1, 1988 ;
