5-甲氧基间苯二甲酸单甲酯合成路线 （共 8 条）
反应条件
1: With sodium hydroxide; water in methanol T=80°C; 2: With hydrogenchloride in water
参考文献
IRM LLC
Patent: WO2007/136465 A2, 2007 ;
Location in patent: Page/Page column 35 ;
WO 2007/136465 A2
反应条件
hydrogenchloride; potassium hydroxide in water 24 h; Inert atmosphere;
参考文献
Fretz, Samuel J.; Hadad, Christopher M.; Hart, David J.; Vyas, Shubham; Yang, Dexi
Journal of Organic Chemistry, 2013 , vol. 78, # 1 p. 83 - 92
反应条件
1: 92 percent / K2CO3 / dimethylformamide / 14 h / 40 °C 2: 33 percent / LiOH / tetrahydrofuran; H2O / 2.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4188 - 4201
反应条件
1: 95 percent / K2CO3 / acetone / Heating 2: 83 percent / 85 percent KOH / methanol; tetrahydrofuran / 6 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 31, # 12 p. 1921 - 1926
反应条件
1.1: sulfuric acid / 22 h / 75 °C / |Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.67 h / |Inert atmosphere; |Cooling with ice 2.2: 2.83 h / |Inert atmosphere 3.1: potassium hydroxide; hydrogenchloride / water / 24 h / |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 1 p. 83 - 92
反应条件
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.67 h / |Inert atmosphere; |Cooling with ice 1.2: 2.83 h / |Inert atmosphere 2.1: potassium hydroxide; hydrogenchloride / water / 24 h / |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 1 p. 83 - 92
反应条件
borane-THF in tetrahydrofuran
T=0 - 20°C; 1 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/32667 A1, 2009 ;
Location in patent: Page/Page column 197 ;
WO 2009/032667 A1
反应条件
1: 90 percent / BH3*(CH3)2S / tetrahydrofuran / 0 - 60 °C
2: 91 percent / MnO2 / ethyl acetate / 5 h / Heating
View Scheme
参考文献
Zhao; Thurkauf
Synthetic Communications, 2001 , vol. 31, # 12 p. 1921 - 1926
