2-(2-甲氧基-2-氧代乙基)苯羧酸甲酯合成路线 （共 48 条）
反应条件
1.1: tert-BuOK; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H9-pyrimidinone
1.2: 74 percent / 24 h / 60 °C
2.1: NaOH / H2O; dioxane
3.1: K2CO3 / dimethylformamide / 3 h / 50 °C
4.1: 95 percent / iron / acetic acid / Heating
View Scheme
参考文献
Bunce, Richard A.; Schammerhorn, James E.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 4 p. 1031 - 1035
反应条件
1: NaH / dimethylsulfoxide; tetrahydrofuran
2: Raney-Ni, aq. NaOH
View Scheme
参考文献
Russell,G.A. et al.
Journal of Organic Chemistry, 1969 , vol. 34, # 8 p. 2339 - 2345
反应条件
1: lithium diisopropylamide / tetrahydrofuran / -78 degC, 2 h, allowed to warm to room temp., room temp., 30 min
2: 83 percent / benzene / 2 h / Ambient temperature
3: NaOH / methanol; H2O / 2 h / Heating
View Scheme
参考文献
Tamura; Sasho; Akai; et al.
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 4 p. 1405 - 1412
反应条件
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 13 h / -78 - 20 °C / Inert atmosphere
2.1: potassium hydroxide / methanol; water / 1 h / Reflux
View Scheme
参考文献
Billamboz, Muriel; Bailly, Fabrice; Lion, Cedric; Calmels, Christina; Andreola, Marie-Line; Witvrouw, Myriam; Christ, Frauke; Debyser, Zeger; De Luca, Laura; Chimirri, Alba; Cotelle, Philippe
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 535 - 546
反应条件
1: 70 percent / sodium hydride / tetrahydrofuran / 5 h / Heating
2: 55 percent / aq. hydrogen peroxide, trifluoroacetic acid / CHCl3 / 6 h / 0 °C
View Scheme
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
反应条件
sodium hydride in tetrahydrofuran
5 h; Heating;
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
Title/Abstract Full Text View citing articles Show Details
Kjaer, Anders; Kjaer, Dana
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 6 p. 417 - 419
反应条件
1: 63 percent / sodium hydride / tetrahydrofuran / 5 h / Heating
2: 52 percent / aq. hydrogen peroxide, trifluoroacetic acid / CHCl3 / 6 h / 0 °C
View Scheme
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
反应条件
sodium hydride in tetrahydrofuran
5 h; Heating;
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
Title/Abstract Full Text View citing articles Show Details
Kjaer, Anders; Kjaer, Dana
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 6 p. 417 - 419
反应条件
1: 52 percent / sodium hydride / tetrahydrofuran / 5 h / Heating
2: 31 percent / aq. hydrogen peroxide, trifluoroacetic acid / CHCl3 / 6 h / 0 °C
View Scheme
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
反应条件
1: 70 percent / sodium hydride / tetrahydrofuran / 5 h / Heating
2: pyridine / 12 h / 20 °C
View Scheme
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
