2-(2-甲氧基-2-氧代乙基)苯羧酸甲酯合成路线 （共 48 条）
反应条件
1: 70 percent / sodium hydride / tetrahydrofuran / 5 h / Heating
2: 55 percent / aq. hydrogen peroxide, trifluoroacetic acid / CHCl3 / 6 h / 0 °C
3: 80 percent / pyridine / 12 h / 20 °C
View Scheme
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
反应条件
1: 70 percent / sodium hydride / tetrahydrofuran / 5 h / Heating
2: 55 percent / aq. hydrogen peroxide, trifluoroacetic acid / CHCl3 / 6 h / 0 °C
3: 98 percent / silver carbonate on Celite / CH2Cl2 / 0.08 h / Ambient temperature
View Scheme
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
反应条件
1: 63 percent / sodium hydride / tetrahydrofuran / 5 h / Heating
2: 52 percent / aq. hydrogen peroxide, trifluoroacetic acid / CHCl3 / 6 h / 0 °C
3: 84 percent / silver carbonate on Celite / CH2Cl2 / 0.08 h / Ambient temperature
View Scheme
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
反应条件
Yield given. Multistep reaction;
参考文献
Kuzma, Peter C.; Brown, Lawrence E.; Harris, Thomas M.
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2015 - 2018
反应条件
1: sodium; diethyl ether / Erwaermen des Reaktionsprodukts auf 100grad.
2: aqueous hydrochloric acid
3: copper-powder / 300 °C
View Scheme
参考文献
Johnston et al.
Journal of Organic Chemistry, 1948 , vol. 13, p. 477,482
反应条件
sodium hydride in tetrahydrofuran
5 h; Heating;
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
Title/Abstract Full Text View citing articles Show Details
Kjaer, Anders; Kjaer, Dana
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 6 p. 417 - 419
反应条件
1: water; potassium carbonate / methanol / 0.75 h / Reflux
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Kilikli, Alper A.; Dengiz, Cagatay; Oezcan, Sevil; Balci, Metin
Synthesis, 2011 , # 22 art. no. T71611SS, p. 3697 - 3705
反应条件
1: 1.) LDA / 1.) hexane, THF, 40 min, 2.) hexane, THF, HMPA, a) -78 deg C, 1 h, b) RT, 1 h
2: 93 percent / aq. KOH / methanol / Heating
View Scheme
参考文献
Billamboz, Muriel; Bailly, Fabrice; Lion, Cedric; Calmels, Christina; Andreola, Marie-Line; Witvrouw, Myriam; Christ, Frauke; Debyser, Zeger; De Luca, Laura; Chimirri, Alba; Cotelle, Philippe
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 535 - 546
