4-(4-甲氧基苯甲酰基)苯甲酸甲酯合成路线 （共 9 条）
反应条件
In(OSO2CF3)3
Friedel-Crafts acylation reaction; 0.0333333 h; microwave irradiation;
参考文献
Koshima, Hideko; Kubota, Masashi
Synthetic Communications, 2003 , vol. 33, # 22 p. 3983 - 3988
反应条件
trifluoromethanesulfonic anhydride in toluene
T=110°C; Friedel Crafts acylation; 1 h;
参考文献
Wilkinson, Mark C.
Organic Letters, 2011 , vol. 13, # 9 p. 2232 - 2235
反应条件
AlCl3, aluminium chloride in chloroform
Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/118542 A1, 2005 ;
Location in patent: Page/Page column 145-146 ;
WO 2005/118542 A1
反应条件
aluminium trichloride in dichloromethane; methoxybenzene
参考文献
Ajinomoto Co., Inc.
Patent: EP976722 A1, 2000 ;
反应条件
1: N-cyclohexyl-4-(methoxycarbonyl)benzamide With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane
T=-78 - 0°C; Inert atmosphere;
2: 4-methoxyphenyl magnesium bromide in dichloromethane
T=0°C; 0.416667 h; Inert atmosphere;
3: With hydrogenchloride; water in tetrahydrofuran; dichloromethane
T=65°C; 3 h; Inert atmosphere; chemoselective reaction;
参考文献
Bechara, William S.; Pelletier, Guillaume; Charette, Andre B.
Nature Chemistry, 2012 , vol. 4, # 3 p. 228 - 234
反应条件
1: (COCl)2; DMF / CH2Cl2 / 1 h / 20 °C
2: CH2Cl2 / 24 h / 20 °C
View Scheme
参考文献
Salem, Ola I. A.; Frotscher, Martin; Scherer, Christiane; Neugebauer, Alexander; Biemel, Klaus; Streiber, Martina; Maas, Ruth; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 748 - 759
反应条件
1.1: 0.5 h / |Reflux; |Inert atmosphere
1.2: 10 h / |Reflux; |Inert atmosphere
2.1: methanol / 0.5 h / 20 °C / |Reflux; |Inert atmosphere
2.2: |Reflux; |Inert atmosphere
3.1: thionyl chloride / 4 h / |Reflux; |Inert atmosphere
4.1: AlCl3, aluminium chloride / chloroform / 10 h / |Reflux; |Inert atmosphere
View Scheme
参考文献
Khan, Ashna A.; Kamena, Faustin; Timmer, Mattie S.M.; Stocker, Bridget L.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 6 p. 881 - 885
反应条件
1.1: methanol / 0.5 h / 20 °C / |Reflux; |Inert atmosphere
1.2: |Reflux; |Inert atmosphere
2.1: thionyl chloride / 4 h / |Reflux; |Inert atmosphere
3.1: AlCl3, aluminium chloride / chloroform / 10 h / |Reflux; |Inert atmosphere
View Scheme
参考文献
Khan, Ashna A.; Kamena, Faustin; Timmer, Mattie S.M.; Stocker, Bridget L.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 6 p. 881 - 885
反应条件
water; lithium hydroxide hydrate in 1,4-dioxane
0.5 h;
参考文献
Bandyopadhyay, Saibal; Bong, Dennis
European Journal of Organic Chemistry, 2011 , # 4 p. 751 - 758
