N-[2-羟基-2-(4-甲氧基苯基)乙基]-2-(2-氯-3,4-二甲氧基苯基)乙胺合成路线 （共 25 条）
反应条件
1: With sodium tetrahydroborate in methanol 1.5 - 2 h; 2: With water in methanol 0.25 h; Product distribution / selectivity;
参考文献
Bigatti, Ettore; Rossetto, Pierluigi; MacDonald, Peter Lindsay
Patent: US2006/194967 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
diborane in tetrahydrofuran 3 h; Heating;
参考文献
Pridgen, Lendon N.; Killmer, Lewis B.; Webb, R. Lee
Journal of Organic Chemistry, 1982 , vol. 47, # 11 p. 1985 - 1989
反应条件
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 2: 19 percent / 2.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
borane in tetrahydrofuran 0.5 h; Heating;
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 50.7 percent / 18 h / Heating 2: 40 percent / BH3 / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 90 percent / Cl2 2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 4: 97 percent / 12N aq. HCl 5: 96 percent / dimethylsulfoxide / 1.25 h 6: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 7: 19 percent / 2.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 96 percent / dimethylsulfoxide / 1.25 h 2: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 3: 19 percent / 2.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 2: 97 percent / 12N aq. HCl 3: 96 percent / dimethylsulfoxide / 1.25 h 4: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 5: 19 percent / 2.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 3: 97 percent / 12N aq. HCl 4: 96 percent / dimethylsulfoxide / 1.25 h 5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 6: 19 percent / 2.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 97 percent / 12N aq. HCl 2: 96 percent / dimethylsulfoxide / 1.25 h 3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 4: 19 percent / 2.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
