N-[2-羟基-2-(4-甲氧基苯基)乙基]-2-(2-氯-3,4-二甲氧基苯基)乙胺合成路线 (共 25 条)
反应条件
sodium hydroxide in CF3 COOH; chloroform
参考文献
Eisai Co., Ltd.
Patent: US5292521 A1, 1994 ;
反应条件
sulfuric acid; trifluoroacetic acid T=25°C; 3.5 h;
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: With sulfuric acid; trifluoroacetic acid in dichloromethane T=0°C; 2 h; 2: With ammonia; water in dichloromethane T=20°C; 3: With hydrogen bromide in water T=107°C; 16 h;
参考文献
Bigatti, Ettore; Rossetto, Pierluigi; MacDonald, Peter Lindsay
Patent: US2006/194967 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 68 percent / H2SO4 / trifluoroacetic acid / 25 °C 2: BBr3 / CH2Cl2 View Scheme
参考文献
Weinstock; Wilson; Ladd; Brush; Pfeiffer; Kuo; Holden; Yim; Hahn; Wardell Jr.; Tobia; Setler; Sarau; Ridley
Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 973 - 975
反应条件
methanesulfonic acid in dichloromethane; water; ethyl acetate
参考文献
SmithKline Beckman Corporation
Patent: US4705862 A1, 1987 ;