lithium hydroxide hydrate in tetrahydrofuran T=20 - 25°C; 1 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; LIN, Shuqun; WEINSTEIN, David S.; WROBLESKI, Stephen T.; ZHANG, Yanlei; TOKARSKI, John S.
Patent: WO2014/74660 A1, 2014 ;
Location in patent: Paragraph 00163 ;
1.1: acetic anhydride / 2 h / 130 °C 1.2: 1 h / 0 °C 1.3: 0.33 h / 20 °C 2.1: N,N-diethylaniline; trichlorophosphate / 21 h / 20 °C / Reflux 3.1: methanol / 3 h / 0 - 20 °C 4.1: lithium hydroxide hydrate / tetrahydrofuran / 3 h / 20 °C View Scheme
