4-氨基-5-(乙基磺酰基)-2-甲氧基苯甲酸合成路线 （共 11 条）
反应条件
1: With dihydrogen peroxide; sodium tungstate in isopropyl alcohol T=40 - 45°C; Industry scale; 2: With water; sodium hydroxide in isopropyl alcohol T=60 - 65°C; Industry scale; 3: With hydrogenchloride in water; isopropyl alcohol pH=4 - 4.5; Industry scale;
参考文献
LUPIN LIMITED; PAGHDAR, Dinesh, Jayntibhai; KOLEKAR, Mahesh, Ramkumar; DESHPANDE, Tushar, Nandkumar; PATIL, Suryaprakash, Pandurang; CHAVAN, Yuvraj, Atmaram; RAY, Purna, Chandra; SINGH, Girij, Pal
Patent: WO2011/158084 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
1.1: bromine / methanol / 5 - 15 °C / Industry scale 2.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale 3.1: sodium hydroxide; water / methanol / 65 °C / Industry scale 3.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale 4.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C View Scheme
反应条件
1.1: potassium hydroxide; tetrabutylammomium bromide / acetone / 1 h / 25 - 35 °C / Industry scale 2.1: bromine / methanol / 5 - 15 °C / Industry scale 3.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale 4.1: sodium hydroxide; water / methanol / 65 °C / Industry scale 4.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale 5.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C View Scheme
反应条件
1.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale 2.1: sodium hydroxide; water / methanol / 65 °C / Industry scale 2.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale 3.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C View Scheme
反应条件
triethylamine in water; ethyl acetate; acetone
参考文献
Societe d'Etudes Scientifiques et Industrielle de l'Ile de France
Patent: US4673686 A1, 1987 ;
反应条件
chloroformic acid ethyl ester; triethylamine in acetone T=0 - 30°C;
参考文献
LUPIN LIMITED; PAGHDAR, Dinesh, Jayntibhai; KOLEKAR, Mahesh, Ramkumar; DESHPANDE, Tushar, Nandkumar; PATIL, Suryaprakash, Pandurang; CHAVAN, Yuvraj, Atmaram; RAY, Purna, Chandra; SINGH, Girij, Pal
Patent: WO2011/158084 A1, 2011 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0°C; 0.5 h; 2: 1-ethyl-2-aminomethylpyrrolidine hydrochloride With triethylamine in dichloromethane T=20°C;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/105755 A1, 2010 ;
Location in patent: Page/Page column 12-13 ;
US 20100105755 A1
反应条件
triethylamine in water; acetone
参考文献
Societe d'Etudes Scientifiques et Industrielles de l'Ile de-France
Patent: US4294828 A1, 1981 ;
反应条件
triethylamine in acetone
参考文献
Societe d'Etudes Scientifiques et Industrielle de l'Ile de France
Patent: US4673686 A1, 1987 ;
反应条件
hydrogenchloride; triethylamine in water; acetone
参考文献
Societe d'Etudes Scientifiques et Industrielles de l'Ile de-France
Patent: US4294828 A1, 1981 ;
