1.1: 4.9 mg / NaOH; NaHSO3 / ethanol / 4 h / 70 - 80 °C 2.1: 74 percent / HBr; AcOH / 16 h / 20 °C 3.1: Li; NH3 / tetrahydrofuran; H2O / 0.75 h / -78 - -33 °C 3.2: 76 percent / tetrahydrofuran; H2O / 2 h / Heating 4.1: 98 percent / KOtBu / toluene / 4 h / Heating 5.1: 100 percent / HCl / tetrahydrofuran / 12 h / 20 °C 6.1: 89 percent / H2; Et3N / 10percent Pd/C / methanol / 12 h / 20 °C 7.1: 98 percent / KOtBu / toluene / 3 h / Heating 8.1: 4 percent / AgO; HNO3 / dioxane / 20 °C View Scheme

1.1: 96 percent / H2SO4 / methanol 2.1: 5.50 mg / NaBH4 / ethanol / 3 h / 0 °C 3.1: 4.9 mg / NaOH; NaHSO3 / ethanol / 4 h / 70 - 80 °C 4.1: 74 percent / HBr; AcOH / 16 h / 20 °C 5.1: Li; NH3 / tetrahydrofuran; H2O / 0.75 h / -78 - -33 °C 5.2: 76 percent / tetrahydrofuran; H2O / 2 h / Heating 6.1: 98 percent / KOtBu / toluene / 4 h / Heating 7.1: 100 percent / HCl / tetrahydrofuran / 12 h / 20 °C 8.1: 89 percent / H2; Et3N / 10percent Pd/C / methanol / 12 h / 20 °C 9.1: 98 percent / KOtBu / toluene / 3 h / Heating 10.1: 4 percent / AgO; HNO3 / dioxane / 20 °C View Scheme

1.1: PbO2 / 20 - 22 °C 2.1: 96 percent / H2SO4 / methanol 3.1: 5.50 mg / NaBH4 / ethanol / 3 h / 0 °C 4.1: 4.9 mg / NaOH; NaHSO3 / ethanol / 4 h / 70 - 80 °C 5.1: 74 percent / HBr; AcOH / 16 h / 20 °C 6.1: Li; NH3 / tetrahydrofuran; H2O / 0.75 h / -78 - -33 °C 6.2: 76 percent / tetrahydrofuran; H2O / 2 h / Heating 7.1: 98 percent / KOtBu / toluene / 4 h / Heating 8.1: 100 percent / HCl / tetrahydrofuran / 12 h / 20 °C 9.1: 89 percent / H2; Et3N / 10percent Pd/C / methanol / 12 h / 20 °C 10.1: 98 percent / KOtBu / toluene / 3 h / Heating 11.1: 4 percent / AgO; HNO3 / dioxane / 20 °C View Scheme

1: 89 percent / H2; Et3N / 10percent Pd/C / methanol / 12 h / 20 °C 2: 98 percent / KOtBu / toluene / 3 h / Heating 3: 4 percent / AgO; HNO3 / dioxane / 20 °C View Scheme

1: 98 percent / KOtBu / toluene / 3 h / Heating 2: 4 percent / AgO; HNO3 / dioxane / 20 °C View Scheme

ammonium cerium(IV) nitrate in water; acetonitrile T=-7 - 20°C; Oxidation; pH=0.7 - 1.3; 11 h;

1: 65 percent / tetrahydrofuran; methanol / 1 h / -20 °C 2: 82 percent / methanol / -20 - 50 °C 3: 78 percent / aq. HClO4 / tetrahydrofuran / 4 h / 25 °C View Scheme

1: 82 percent / methanol / -20 - 50 °C 2: 78 percent / aq. HClO4 / tetrahydrofuran / 4 h / 25 °C View Scheme

1: 26 percent / AgO; HNO3 / dioxane / 20 °C 2: 72 percent / aq. KOH / methanol / 20 °C View Scheme

1: 96 percent / H2SO4 / methanol 2: 72 percent / aq. KOH / methanol / 20 °C View Scheme