3-氧代-3-[4-(三氟甲基)苯基]丙腈合成路线 （共 8 条）
反应条件
1: With acetonitrile in chlorobenzene 30 h; 2: With sodium methylate
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/785 A2, 2003 ;
Location in patent: Page 25 ;
WO 2004/000785 A2
反应条件
bromobenzene Ambient temperatureelectrolysis;
参考文献
Barhdadi, Rachid; Gal, Jacques; Heintz, Monique; Troupel, Michel
Journal of the Chemical Society, Chemical Communications, 1992 , # 1 p. 50 - 51
反应条件
hydrogenchloride in chloroform
参考文献
Journal of Medicinal Chemistry, , vol. 22, # 11 p. 1385 - 1389
反应条件
1: NaH, tBuOH / diethyl ether / Heating 2: aq. HCl / CHCl3 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 22, # 11 p. 1385 - 1389
反应条件
toluene-4-sulfonic acid in toluene 18 h; Heating; Yield given;
参考文献
Synthesis, , # 3 p. 337 - 341
反应条件
1: 1.) NaH / 1.) toluene, below 20 deg C, 2.) toluene, overnight 2: p-TsOH / toluene / 18 h / Heating View Scheme
参考文献
Synthesis, , # 3 p. 337 - 341
反应条件
n-butyllithium 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, 40 min; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 11 p. 3295 - 3301
反应条件
hydrazine in ethanol 2 h; RefluxInert atmosphere;
参考文献
Moe, Scott T.; Thompson, Andrew B.; Smith, Genessa M.; Fredenburg, Ross A.; Stein, Ross L.; Jacobson, Alan R.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3072 - 3079
