1-苄基嘧啶-2,4-二酮合成路线 （共 26 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
T=100°C; Alkylation; 48 h;
参考文献
Zimmerman, Michael N.; Nemeroff, Norman H.; Bock, Charles W.; Bhat, Krishna L.
Heterocycles, 2000 , vol. 53, # 1 p. 205 - 211
反应条件
ammonium hydroxide; zinc in ethanol
T=90°C; 4 h;
参考文献
Nagamatsu, Tomohisa; Yamasaki, Hirofumi; Yoneda, Fumio
Heterocycles, 1994 , vol. 37, # 2 p. 1147 - 1164
反应条件
potassium carbonate in dimethyl sulfoxide
T=60 - 70°C; 1 h;
参考文献
Ishikawa; Itoh; Takayanagi; Oshima; Kawahara; Mizuno; Ogura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 8 p. 1922 - 1930
反应条件
lithium hydride in 1,4-dioxane
T=60°C; Alkylation; demethylation; 24 h;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
iodine in 1,2-dichloro-ethane
24 h; Heating;
参考文献
Malik, Vaishali; Singh, Palwinder; Kumar, Subodh
Tetrahedron, 2005 , vol. 61, # 16 p. 4009 - 4014
反应条件
palladium diacetate; caesium carbonate in N,N-dimethyl-formamide
T=100°C; 2 h; Inert atmosphere;
参考文献
Liang, Yong; Gloudeman, Jennifer; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4094 - 4103
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride in tetrahydrofuran; water; N,N-dimethyl-formamide
T=100°C; 1 h; Inert atmosphere;
参考文献
Liang, Yong; Gloudeman, Jennifer; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4094 - 4103
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride in tetrahydrofuran; water; N,N-dimethyl-formamide
T=100°C; 1 h; Inert atmosphere;
参考文献
Liang, Yong; Gloudeman, Jennifer; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4094 - 4103
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride in tetrahydrofuran; water; N,N-dimethyl-formamide
T=100°C; 1 h; Inert atmosphere;
参考文献
Liang, Yong; Gloudeman, Jennifer; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4094 - 4103
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
Reflux;
参考文献
Rad, Mohammad Navid Soltani; Khalafi-Nezhad, Ali; Divar, Masoumeh; Behrouz, Somayeh
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 9 p. 1943 - 1954
