3-羟基-4-硝基苯甲酸乙酯合成路线 （共 4 条）
反应条件
sulfuric acid 2 h; Heating;
参考文献
UNIVERSITY OF LJUBLJANA; LEK PHARMACEUTICALS d.d.
Patent: WO2005/51934 A1, 2005 ;
Location in patent: Page/Page column 43-45 ;
反应条件
1: 100 percent / H2 / Pd/C / ethanol / 20 °C
2: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
3: 83 percent / aq. NaHCO3 / 1 h / Heating
View Scheme
参考文献
Anderluh, Petra Stefanic; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Dolenc, Marija Sollner; Stegnar, Mojca; Kikelj, Danijel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3110 - 3113
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=20°C;
参考文献
UNIVERSITY OF LJUBLJANA; LEK PHARMACEUTICALS d.d.
Patent: WO2005/51934 A1, 2005 ;
Location in patent: Page/Page column 44-45 ;
反应条件
1: 85 percent / Et3N / acetone / 15 h / 25 °C
2: 75 percent / NaH / dimethylformamide / 24 h / 25 °C
3: 82 percent / iron powder / acetic acid / 2 h / Heating
View Scheme
参考文献
Decodts; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 2 p. 107 - 111
