3-甲基-1H-1,2,4-噻唑合成路线 （共 12 条）
反应条件
1: 1-Imino-ethanamine hydrochloride With sodium methylate in ethanol T=0 - 20°C; 2: hydrazinecarboxaldehyde T=55°C; 17 h;
参考文献
US2006/293304 A1, ;
Page/Page column 31 ;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 49, # 11 p. 2492 - 2495
反应条件
phosphoric acid; sodium nitrite T=0 - 20°C;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 1-2 p. 103 - 116
反应条件
nitric acid; sodium nitrite
参考文献
Journal of the American Chemical Society, , vol. 77, p. 1538
反应条件
sodium tetrahydroborate in ethanol 3 h; Heating; Yield given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 46, # 2 p. 641 - 648
反应条件
hypophosphorous acid; sodium nitrite
参考文献
Journal of Organic Chemistry, , vol. 18, p. 218,227
反应条件
hydrogenchloride; water; sodium lauryl sulfate in acetonitrile T=25°C; var. conc. of surfactants in other solvents; Rate constantMechanism;
参考文献
Journal of Organic Chemistry, , vol. 47, # 1 p. 152 - 154
反应条件
potassium hydroxide in 1,4-dioxane
参考文献
Trzhtsinskaya, B. V.; Apakina, E. V.; Afonin, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 4.2 p. 834 - 836
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 4 p. 928 - 931
反应条件
copper; potassium carbonate
T=170 - 175°C; 12 h;
参考文献
Ueda, Yasutsugu; Connolly, Timothy P.; Kadow, John F.; Meanwell, Nicholas A.; Wang, Tao; Chen, Chung-Pin H.; Yeung, Kap-Sun; Zhang, Zhongxing; Leahy, David Kenneth; Pack, Shawn K.; Soundararajan, Nachimuthu; Sirard, Pierre; Levesque, Kathia; Thoraval, Dominique
Patent: US2005/209246 A1, 2005 ;
Location in patent: Page/Page column 27; 28 ;
反应条件
T=110 - 144°C; 17 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2006/293304 A1, 2006 ;
Location in patent: Page/Page column 31 ;
