2,6-吡啶二羧酸单甲酯合成路线 （共 13 条）
反应条件
1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C 2: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling 3: toluene / 30 h / 120 °C 4: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C View Scheme
参考文献
Zhao, Huaiqing; Ong, Wei Qiang; Fang, Xiao; Zhou, Feng; Hii, Meng Ni; Li, Sam Fong Yau; Su, Haibin; Zeng, Huaqiang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1172 - 1180
反应条件
diphenyl phosphoryl azide; benzotriazol-1-ol; triethylamine in toluene T=100°C;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/117754 A1, 2006 ;
Location in patent: Page/Page column 51 ;
WO 2006/117754 A1
反应条件
thionyl chloride in benzene
T=50°C; 8 h;
参考文献
Elhabiri, Mourad; Scopelliti, Rosario; Buenzli, Jean-Claude G.; Piguet, Claude
Journal of the American Chemical Society, 1999 , vol. 121, # 46 p. 10747 - 10762
