3-溴-2-氯-5-三氟甲基吡啶合成路线 （共 4 条）
反应条件
1: With trichlorophosphate T=100°C; 5 h; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/73934 A1, 2007 ;
Location in patent: Page/Page column 75 ;
反应条件
1: With hydrogenchloride; sodium nitrite in 1,4-dioxane; water T=0 - 20°C; 3 h; 2: With trichlorophosphate T=80°C; 3 h;
参考文献
EP1012142 B1, ;
Page 36 ;
反应条件
n-butyllithium in hexane; toluene T=-65°C; 0.5 h;
参考文献
NOVARTIS AG
Patent: WO2008/58967 A1, 2008 ;
Location in patent: Page/Page column 45 ;
反应条件
sodium methylate in methanol
参考文献
The Dow Chemical Company
Patent: US4931452 A1, 1990 ;
