6-氯-1H-吲唑-3-羧酸甲酯合成路线 （共 3 条）
反应条件
1,1-dimethylnitroethane in acetic acid T=90°C; 1 h; Acidic conditions;
参考文献
PFIZER INC.
Patent: WO2004/56806 A1, 2004 ;
Location in patent: Page 37 ;
WO 2004/056806 A1
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine in toluene T=70°C; P=750.075 Torr; Autoclave;
参考文献
Buchstaller, Hans-Peter; Wilkinson, Kai; Burek, Kasimir; Nisar, Yasmin
Synthesis, 2011 , # 19 art. no. T48411SS, p. 3089 - 3098
反应条件
1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine / toluene / 70 °C / 750.08 Torr / Autoclave View Scheme
参考文献
Synthesis, , # 19 art. no. T48411SS, p. 3089 - 3098
