反应条件
1: 76 percent / H2NNH2*H2O, KOH / various solvent(s) / 4 h / 210 °C 2: SnCl4 / 1,2-dichloro-ethane / 1 h / Ambient temperature 3: H2NNH2*H2O, KOH / various solvent(s) / 4 h / 210 °C 4: 76 percent / LiAlH4 / diethyl ether / 2 h / Ambient temperature 5: 89 percent / 1,1'-carbonyldiimidazole, allyl bromide / acetonitrile / 2 h / Heating 6: 1.) LDA, HMPA / 1.) THF, hexane, 50 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h View Scheme
参考文献
Labaudiniere, Richard; Hilboll, Gerd; Leon-Lomeli, Alicia; Terlain, Bernard; Cavy, Francoise; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3170 - 3179