3-羟基-4-(羟基甲基)-苯甲酸甲酯合成路线 （共 11 条）
反应条件
sodium tetrahydroborate in methanol
T=20°C; 1 h;
参考文献
Weinert, Emily E.; Dondi, Ruggero; Colloredo-Melz, Stefano; Frankenfield, Kristen N.; Mitchell, Charles H.; Freccero, Mauro; Rokita, Steven E.
Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11940 - 11947
反应条件
triethylamine; palladium diacetate in methanol
参考文献
Centre International De Recherches Dermatologiques Galderma
Patent: US5849798 A1, 1998 ;
反应条件
sodium hydrogencarbonate in acetonitrile
T=80°C;
参考文献
Weinert, Emily E.; Dondi, Ruggero; Colloredo-Melz, Stefano; Frankenfield, Kristen N.; Mitchell, Charles H.; Freccero, Mauro; Rokita, Steven E.
Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11940 - 11947
反应条件
1: 99 percent / sodium hydroxide; sodium acetate / Cu / H2O / 80 h / Heating
2: 84 percent / sulfuric acid / 24 h / Heating
3: 75 percent / sodium borohydride / methanol / 1 h / 20 °C
View Scheme
参考文献
Weinert, Emily E.; Dondi, Ruggero; Colloredo-Melz, Stefano; Frankenfield, Kristen N.; Mitchell, Charles H.; Freccero, Mauro; Rokita, Steven E.
Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11940 - 11947
反应条件
hydrogenchloride; sodium borohydride in methanol; benzene
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US4335250 A1, 1982 ;
反应条件
1: 84 percent / sulfuric acid / 24 h / Heating
2: 75 percent / sodium borohydride / methanol / 1 h / 20 °C
View Scheme
参考文献
Weinert, Emily E.; Dondi, Ruggero; Colloredo-Melz, Stefano; Frankenfield, Kristen N.; Mitchell, Charles H.; Freccero, Mauro; Rokita, Steven E.
Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11940 - 11947
反应条件
1: 70 percent / K2CO3 / CH2Cl2 / 120 h / 20 °C
2: aq. NaHCO3 / acetonitrile / 80 °C
View Scheme
参考文献
Weinert, Emily E.; Dondi, Ruggero; Colloredo-Melz, Stefano; Frankenfield, Kristen N.; Mitchell, Charles H.; Freccero, Mauro; Rokita, Steven E.
Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11940 - 11947
反应条件
palladium diacetate; triethylamine
参考文献
Diaz; Michel; Stella; Charpentier
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2289 - 2294
参考文献
Matter, Hans; Will, David W.; Nazare, Marc; Schreuder, Herman; Laux, Volker; Wehner, Volkmar
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3290 - 3312
反应条件
1: 1.) NaNO2, KI, CuI, H2SO4, 2.) BH3 / 2.) THF
2: 70 percent / Pd(OAc)2, Et3N
View Scheme
参考文献
Diaz; Michel; Stella; Charpentier
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2289 - 2294
