1-(4-氯苯基)甲烷磺酰胺合成路线 （共 5 条）
反应条件
ammonia in methanol
Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2007/8140 A1, 2007 ;
Location in patent: Page/Page column 82; 153 ;
WO 2007/008140 A1
反应条件
acetone; zinc in acetic acid
T=25°C; 2.5 h;
参考文献
Chan, Wing Yan; Berthelette, Carl
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4537 - 4540
反应条件
1: Na2WO4; H2O2 / methanol
2: NaBH4 / methanol; tetrahydrofuran
3: 85 percent / TFA / tetrahydrofuran / 0.5 h / 0 °C
4: 95 percent / Zn; acetone / acetic acid / 2.5 h / 25 °C
View Scheme
参考文献
Chan, Wing Yan; Berthelette, Carl
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4537 - 4540
反应条件
1: NaH / dimethylformamide
2: Na2WO4; H2O2 / methanol
3: NaBH4 / methanol; tetrahydrofuran
4: 85 percent / TFA / tetrahydrofuran / 0.5 h / 0 °C
5: 95 percent / Zn; acetone / acetic acid / 2.5 h / 25 °C
View Scheme
参考文献
Chan, Wing Yan; Berthelette, Carl
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4537 - 4540
反应条件
1: NaBH4 / methanol; tetrahydrofuran
2: 85 percent / TFA / tetrahydrofuran / 0.5 h / 0 °C
3: 95 percent / Zn; acetone / acetic acid / 2.5 h / 25 °C
View Scheme
参考文献
Chan, Wing Yan; Berthelette, Carl
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4537 - 4540
