1,1,1,3,3,3-六氟代-2-苯基-2-丙醇合成路线 （共 34 条）
反应条件
1: 90 percent / aq. HNO3; H2SO4 / 2.3 h / 0 - 20 °C 2: 100 percent / H2 / Pd/C / ethanol / 6 h / 20 °C View Scheme
参考文献
Sheppard,W.A.
Journal of the American Chemical Society, 1965 , vol. 87, # 11 p. 2410 - 2420
反应条件
sulfuric acid; nitric acid T=0 - 20°C; 2.3 h;
参考文献
Li, Leping; Liu, Jiwen; Zhu, Liusheng; Cutler, Serena; Hasegawa, Hirohiko; Shan, Bei; Medina, Julio C.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1638 - 1642
反应条件
1.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 18.5 h / 0 - 23 °C / Inert atmosphere
1.2: 4.5 h / 0 - 23 °C / Inert atmosphere
2.1: tert-butylhypochlorite / dichloromethane / 0.5 h / 0 °C
View Scheme
参考文献
Li, Yifan; Brand, Jonathan P.; Waser, Jerome
Angewandte Chemie - International Edition, 2013 , vol. 52, # 26 p. 6743 - 6747
反应条件
sodium methylate in methanol
T=20°C; 0.166667 h; Product distribution / selectivity;
参考文献
3M innovative Properties Company
Patent: US2006/135827 A1, 2006 ;
Location in patent: Page/Page column 8; 9 ;
