[PdCl2(1,3-bis(diphenylphosphino)propane)]; lithium triethylborohydride in tetrahydrofuran T=0 - 20°C; 10 h; Inert atmosphere;

lithium; ethylamine in diethyl ether T=-78°C; 1 h;

2: 1.) n-BuLi, 3.) H2O, KOH 3: 63 percent / Li, ethylamine / diethyl ether / 1 h / -78 °C 4: 1.) PBr3, pyridine / 1.) ether, 2.) DMF, ambient temperature 5: 1.) n-BuLi, 3.) H2O, KOH 6: 70 percent / Li, ethylamine / diethyl ether 7: 1.) n-BuLi / 1.) THF, HMPA, 2.) -78 deg C 8: 50 percent / Li, ethylamine / diethyl ether / -78 °C View Scheme

1: 264 mg / Li, ethylamine / diethyl ether / 1 h / -78 °C 2: 91 percent / PBr3, pyridine / diethyl ether / 6 h / -5 °C View Scheme