2-甲基-2-(4-硝基苯基)丙腈合成路线 （共 15 条）
反应条件
sulfuric acid; water Heating / reflux;
参考文献
F2G LTD
Patent: WO2008/62182 A1, 2008 ;
Location in patent: Page/Page column 120 ;
反应条件
1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 10 h / 20 °C / 2068.65 Torr 2: acetic acid / 2 h View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
反应条件
1: hydrogenchloride; NaOH; BH3 / tetrahydrofuran 2: NaOH / 1,4-dioxane; water 3: ammonium formate / ethanol View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
反应条件
1: ethanol; aqueous Na2S2O4 2: concentrated aqueous HCl View Scheme
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
反应条件
carbon palladium in ethyl acetate
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/137595 A1, 2009 ;
反应条件
in ethyl acetate 3 h; Reflux;
参考文献
Glenmark Pharmaceuticals S.A.
Patent: US2012/108583 A1, 2012 ;
Location in patent: Page/Page column 29 ;
US 20120108583 A1
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane; water
参考文献
Axton, Christopher A.; Billingham, Michael E. J.; Bishop, Paul M.; Gallagher, Peter T.; Hicks, Terence A.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 17 p. 2203 - 2214
反应条件
1: (4-nitro-phenyl)-acetonitrile With sodium hydroxide; tetra-(n-butyl)ammonium iodide in dichloromethane; water
T=0°C; 0.5 h;
2: methyl iodide in dichloromethane; water
T=20°C;
参考文献
F2G LTD
Patent: WO2006/123145 A1, 2006 ;
Location in patent: Page/Page column 49-50 ;
反应条件
in sodium hydroxide; dichloromethane
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/137595 A1, 2009 ;
