2-甲基-2-(4-硝基苯基)丙腈合成路线 （共 15 条）
反应条件
bis(η3-allyl-μ-chloropalladium(II)); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,3,5-trimethyl-benzene
T=20 - 140°C; 10.1667 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Shang, Rui; Ji, Dong-Sheng; Chu, Ling; Fu, Yao; Liu, Lei
Angewandte Chemie - International Edition, 2011 , vol. 50, # 19 p. 4470 - 4474
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide
0.15 h;
参考文献
Kornblum, Nathan; Cheng, Leung; Davies, Thomas M.; Earl, Gary W.; Holy, Norman L; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 2 p. 196 - 204
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
反应条件
1: hydrogen / tetrahydrofuran; methanol / 12 h / 20 °C / 825.08 Torr
2: acetic acid / 2 h
3: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
4: triethylamine / dichloromethane / 1 h / 0 °C
5: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 10 h / 20 °C / 2068.65 Torr
2: acetic acid / 2 h
3: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
